Early detection of multiple myeloma in primary care using blood tests: a case–control study in primary care

This UK based, matched case-control study examined the combined predictive value of presenting symptoms and blood tests commonly used in primary care in order to find which are useful in suggesting/excluding a diagnosis of multiple myeloma. Using data from over 2,700 cases and more than 12,000 controls, the study found that plasma viscosity (PV) and ESR were better than C-reactive protein for ruling in/out myeloma. Additionally, a combination of a normal ESR or PV and normal haemoglobin could be a simple rule-out approach for patients being tested in primary care.  Though more research is needed, these results could help doctors to shorten the diagnostic interval for this rare, fatal, cancer. Read the full article here. Read the corresponding editorial here.