Research Round-up – October 2018 – Mark Nelson

Kristi Milley and Sophie Chima talk to  Professor Mark Nelson  about the results of his recently published ASPREE trials, (ASPirin in Reducing Events in the Elderly). The guidelines around daily aspirin for prevention of colorectal cancer have recently been updated in Australia, however aspirin still does not feature in UK guidelines. Recent studies have implied aspirin may aid prevention or delaying of the onset of cardiovascular disease, dementia, depression and some types of cancer. Professor Nelson describes in detail the results of the ASPREE trials, which found no benefit in healthy adults, aged 70 and above. The podcast explores the complexity of international trials, the use composite outcomes and how these results will shape future work.

 

Articles

McNeil JJ, Woods RL, Nelson MR, et al. Effect of Aspirin on Disability-free Survival in the Healthy Elderly. The New England Journal of Medicine. 2018; 379:1499-1508 doi: 10.1056/NEJMoa1800722

McNeil JJ, Nelson MR, Woods RL, et al. Effect of Aspirin on All-Cause Mortality in the Healthy Elderly. The New England Journal of Medicine. 2018; 379:1519-1528 doi: 10.1056/NEJMoa1803955

McNeil JJ, Woolfe, R, Woods RL, et al. Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly. The New England Journal of Medicine 2018; 379:1509-1518 doi: 10.1056/NEJMoa1805819 

 

Available on your favourite podcast players