Effectiveness of a Mailed Colorectal Cancer Screening Outreach Program in Community Health Clinics The STOP CRC Cluster Randomized Clinical Trial

This US based RCT investigated the effectiveness of an electronic health record (EHR)-embedded
mailed fecal immunochemical test (FIT) outreach program implemented in health centers as part of standard care. The study included 26 clinics with over 40,000 eligible patients. The intervention included an introductory letter, a mailed test and a reminder letter. Overall, the intervention increased completed FIT screening by 3.4% and any colorectal cancer screening by 3.8%. There was also a wide variation in screening between participating health clinics highlighting the challenges of implementing new interventions within primary care clinics. The low levels of implementation were associated with low levels of effectiveness.

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